ABSTRACT

Amiodarone is a potent, iodine rich, highly lipophilic class III antiarrhythmic drug widely used for the manage- ment of both supraventricular and ventricular arrhythmias. It tends to concentrate in tissues including fat, lung, liver cornea and skin. Several side effects have been reported in patients taking amiodarone. The mecha- nisms of amiodarone-induced side effects are poorly understood. Accumulation of amiodarone in tissues and organs has been suggested as a possible mechanism. The most frequent dermatologic side effects are photosen- sitivity, skin discoloration and erythema. This article presents the case of a patient who developed amiodarone- induced bullous skin lesions and hepatotoxicity.